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"Next-generation DNA sequencing (NGS) technology has revolutionized biomedical research, making genome and RNA sequencing an affordable and frequently used tool for a wide variety of research applications including variant (mutation) discovery, gene expression, transcription factor analysis, metagenomics, and epigenetics. Bioinformatics methods to support DNA sequencing have become and remain a critical bottleneck for many researchers and organizations wishing to make use of NGS technology. Next-Generation DNA Sequencing Bioinformatics, Second Edition, provides thorough, plain language introduction to the necessary informatics methods and tools for analyzing NGS data as did the first edition, and provides detailed descriptions of algorithms, strengths and weaknesses of specific tools, pitfalls and alternative methods. Four new chapters in this edition cover: experimental design, sample preparation, and quality assessment of NGS data; Public databases for DNA Sequencing data; De novo transcript assembly; proteogenomics; and emerging sequencing technologies. The remaining chapters from the first edition have been updated with the latest information. This book also provides extensive reference to best-practice bioinformatics methods for NGS applications and tutorials for common workflows. The second edition of Next-Generation DNA Sequencing Bioinformatics addresses the informatics needs of students, laboratory scientists, and computing specialists who wish to take advantage of the explosion of research opportunities offered by new DNA sequencing technologies"-- "Next-generation DNA sequencing (NGS) technology has revolutionized biomedical research, making complete genome sequencing an affordable and frequently used tool for a wide variety of research applications. This book provides a thorough introduction to the necessary informatics methods and tools for operating NGS instruments and analyzing NGS data"--

medische informatica --- Human genetics --- DNA --- Molecular biology --- Human medicine --- medische genetica --- Nucleotide sequence --- Bioinformatics --- Nucleotide sequence. --- Bioinformatics. --- Sequence Analysis, DNA --- Computational Biology --- Analysis, DNA Sequence --- DNA Sequence Determination --- DNA Sequence Determinations --- DNA Sequencing --- Determination, DNA Sequence --- Determinations, DNA Sequence --- Sequence Determinations, DNA --- DNA Sequence Analysis --- Sequence Determination, DNA --- Analyses, DNA Sequence --- DNA Sequence Analyses --- Sequence Analyses, DNA --- Sequencing, DNA --- Genomics --- Molecular Sequence Annotation --- Bio-informatics --- Biological informatics --- Biology --- Information science --- Computational biology --- Systems biology --- Analysis, Nucleic acid sequence --- Analysis, Nucleotide sequence --- Base sequence (Nucleic acids) --- DNA sequence --- Nucleic acid sequence analysis --- Nucleotide sequence analysis --- RNA sequence --- Sequence, Nucleotide --- Nucleic acids --- Nucleotides --- Sequence alignment (Bioinformatics) --- methods --- Data processing --- Analysis

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Nucleotide sequence --- Mitochondrial DNA --- Mitochondrial DNA. --- Nucleotide sequence. --- DNA, Mitochondrial --- Sequence Analysis, DNA --- Analysis, Nucleic acid sequence --- Analysis, Nucleotide sequence --- Base sequence (Nucleic acids) --- DNA sequence --- Nucleic acid sequence analysis --- Nucleotide sequence analysis --- RNA sequence --- Sequence, Nucleotide --- Mitochondrial genome --- Mitochondrial genomes --- mtDNA --- Analysis, DNA Sequence --- DNA Sequence Determination --- DNA Sequence Determinations --- DNA Sequencing --- Determination, DNA Sequence --- Determinations, DNA Sequence --- Sequence Determinations, DNA --- DNA Sequence Analysis --- Sequence Determination, DNA --- Analyses, DNA Sequence --- DNA Sequence Analyses --- Sequence Analyses, DNA --- Sequencing, DNA --- Nucleic acids --- Nucleotides --- Sequence alignment (Bioinformatics) --- Extrachromosomal DNA --- Genomics --- Molecular Sequence Annotation --- Extrachromosomal Inheritance --- Genes, Mitochondrial --- Analysis --- DNA, Mitochondrial. --- Sequence Analysis, DNA. --- Animal Biochemistry

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Molecular genetics --- Gene mapping --- Nucleotide sequence --- Base Sequence. --- Chromosome Mapping. --- Genome. --- Sequence Analysis, DNA. --- Gene mapping. --- Molecular genetics. --- Nucleotide sequence. --- Chromosome mapping --- Genetic mapping --- Genome mapping --- Linkage mapping (Genetics) --- Mapping, Gene --- Analysis, DNA Sequence --- DNA Sequence Determination --- DNA Sequence Determinations --- DNA Sequencing --- Determination, DNA Sequence --- Determinations, DNA Sequence --- Sequence Determinations, DNA --- DNA Sequence Analysis --- Sequence Determination, DNA --- Analyses, DNA Sequence --- DNA Sequence Analyses --- Sequence Analyses, DNA --- Sequencing, DNA --- Genomes --- Genome Mapping --- Gene Mapping --- Linkage Mapping --- Chromosome Mappings --- Gene Mappings --- Genome Mappings --- Linkage Mappings --- Mapping, Chromosome --- Mapping, Genome --- Mapping, Linkage --- Mappings, Chromosome --- Mappings, Gene --- Mappings, Genome --- Mappings, Linkage --- DNA Sequences --- DNA Sequence --- Nucleotide Sequence --- RNA Sequence --- Base Sequences --- Nucleotide Sequences --- RNA Sequences --- Sequence, Base --- Sequence, DNA --- Sequence, Nucleotide --- Sequence, RNA --- Sequences, Base --- Sequences, DNA --- Sequences, Nucleotide --- Sequences, RNA --- Analysis, Nucleic acid sequence --- Analysis, Nucleotide sequence --- Base sequence (Nucleic acids) --- DNA sequence --- Nucleic acid sequence analysis --- Nucleotide sequence analysis --- RNA sequence --- Genetics --- Genomics --- Molecular Sequence Annotation --- Genes --- Proteome --- Cytogenetics --- Genetic Markers --- Cytogenetic Analysis --- Gene Order --- Synteny --- Nucleotides --- Nucleic acids --- Sequence alignment (Bioinformatics) --- Molecular biology --- Technique --- Analysis --- Base Sequence --- Chromosome Mapping --- Genome --- Sequence Analysis, DNA

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The storage, processing, description, transmission, connection, and analysis of the waves of new genomic data have made bioinformatics skills essential for scientists working with DNA sequences. In Bioinformatics for DNA Sequence Analysis, experts in the field provide practical guidance and troubleshooting advice for the computational analysis of DNA sequences, covering a range of issues and methods that unveil the multitude of applications and the vital relevance that the use of bioinformatics has today. Individual book chapters explore the use of specific bioinformatic tools, accompanied by practical examples, a discussion on the interpretation of results, and specific comments on strengths and limitations of the methods and tools. As a part of the highly successful Methods in Molecular Biology™ series, this work provides the kind of detailed description and implementation advice that is crucial for getting optimal results. Focused and cutting-edge, Bioinformatics for DNA Sequence Analysis serves molecular biologists, geneticists, and biochemists as an enriched task-oriented manual, offering step-by-step guidance for the analysis of DNA sequences in a simple but meaningful fashion.

Sequence Analysis, DNA --- Computational Biology --- Bioinformatics --- Nucleotide sequence --- Bio-informatique --- Génome humain --- methods --- Laboratory manuals --- Manuels de laboratoire --- Séquençage --- Methods --- Biology --- Sequence Analysis --- Investigative Techniques --- Genetic Techniques --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Biological Science Disciplines --- Natural Science Disciplines --- Disciplines and Occupations --- Biology - General --- Health & Biological Sciences --- Génome humain --- Séquençage --- Analysis, Sequence --- Determination, Sequence --- Determinations, Sequence --- Sequence Determinations --- Sequence Determination --- Analyses, Sequence --- Sequence Analyses --- Bio-Informatics --- Biology, Computational --- Computational Molecular Biology --- Molecular Biology, Computational --- Bio Informatics --- Bio-Informatic --- Bioinformatic --- Biologies, Computational Molecular --- Biology, Computational Molecular --- Computational Molecular Biologies --- Molecular Biologies, Computational --- Natural Sciences --- Physical Sciences --- Discipline, Natural Science --- Disciplines, Natural Science --- Natural Science --- Natural Science Discipline --- Physical Science --- Science, Natural --- Science, Physical --- Sciences, Natural --- Sciences, Physical --- Biologic Sciences --- Biological Science --- Science, Biological --- Sciences, Biological --- Biological Sciences --- Life Sciences --- Biologic Science --- Biological Science Discipline --- Discipline, Biological Science --- Disciplines, Biological Science --- Life Science --- Science Discipline, Biological --- Science Disciplines, Biological --- Science, Biologic --- Science, Life --- Sciences, Biologic --- Sciences, Life --- Genetic Technic --- Genetic Technics --- Genetic Technique --- Technic, Genetic --- Technics, Genetic --- Technique, Genetic --- Techniques, Genetic --- Genetics --- Investigative Technics --- Investigative Technic --- Investigative Technique --- Technic, Investigative --- Technics, Investigative --- Technique, Investigative --- Techniques, Investigative --- Methodological Studies --- Methodological Study --- Procedures --- Studies, Methodological --- Study, Methodological --- Method --- Procedure --- Analysis, DNA Sequence --- DNA Sequence Determination --- DNA Sequence Determinations --- DNA Sequencing --- Determination, DNA Sequence --- Determinations, DNA Sequence --- Sequence Determinations, DNA --- DNA Sequence Analysis --- Sequence Determination, DNA --- Analyses, DNA Sequence --- DNA Sequence Analyses --- Sequence Analyses, DNA --- Sequencing, DNA --- Analysis, Nucleic acid sequence --- Analysis, Nucleotide sequence --- Base sequence (Nucleic acids) --- DNA sequence --- Nucleic acid sequence analysis --- Nucleotide sequence analysis --- RNA sequence --- Sequence, Nucleotide --- Bio-informatics --- Biological informatics --- methods. --- Information science --- Computational biology --- Systems biology --- Nucleic acids --- Nucleotides --- Sequence alignment (Bioinformatics) --- Data processing --- Analysis --- Bioinformatics. --- Human genetics. --- Human Genetics. --- Heredity, Human --- Human biology --- Physical anthropology

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A DNA barcode in its simplest definition is one or more short gene sequences taken from a standardized portion of the genome that is used to identify species through reference to DNA sequence libraries or databases. In DNA Barcodes: Methods and Protocols expert researchers in the field detail many of the methods which are now commonly used with DNA barcodes. These methods include the latest information on techniques for generating, applying, and analyzing DNA barcodes across the Tree of Life including animals, fungi, protists, algae, and plants. Written in the highly successful  Methods in Molecular Biology™ series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory.   Thorough and intuitive, DNA Barcodes: Methods and Protocols aids scientists in continuing to study methods from wet-lab protocols, statistical, and ecological analyses along with guides to future, large-scale collections campaigns.

DNA Barcoding, Taxonomic --- Data Mining --- Genetic markers. --- DNA data banks. --- Marqueurs génétiques --- Banques de données génétiques (Génétique légale) --- methods --- Genetic markers --- DNA data banks --- Information Storage and Retrieval --- Publication Formats --- Sequence Analysis, DNA --- Molecular Typing --- Investigative Techniques --- Medical Informatics Applications --- Information Science --- Sequence Analysis --- Genetic Techniques --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Publication Characteristics --- Medical Informatics --- Laboratory Manuals --- Methods --- Biology --- Health & Biological Sciences --- Genetics --- Marqueurs génétiques --- Banques de données génétiques (Génétique légale) --- Methodological Studies --- Methodological Study --- Procedures --- Studies, Methodological --- Study, Methodological --- Method --- Procedure --- Text Mining --- Mining, Data --- Mining, Text --- DNA Barcode, Taxonomic --- Phylogenetic DNA Barcode --- Phylogenetic DNA Barcoding --- Taxonomic DNA Barcode --- Taxonomic DNA Barcodes --- Taxonomic DNA Barcoding --- Barcode, Phylogenetic DNA --- Barcode, Taxonomic DNA --- Barcodes, Phylogenetic DNA --- Barcodes, Taxonomic DNA --- Barcoding, Phylogenetic DNA --- Barcoding, Taxonomic DNA --- Barcodings, Phylogenetic DNA --- Barcodings, Taxonomic DNA --- DNA Barcode, Phylogenetic --- DNA Barcodes, Phylogenetic --- DNA Barcodes, Taxonomic --- DNA Barcoding, Phylogenetic --- DNA Barcodings, Phylogenetic --- DNA Barcodings, Taxonomic --- Phylogenetic DNA Barcodes --- Phylogenetic DNA Barcodings --- Taxonomic DNA Barcodings --- Computer Science, Medical --- Health Information Technology --- Informatics, Clinical --- Informatics, Medical --- Information Science, Medical --- Clinical Informatics --- Medical Computer Science --- Medical Information Science --- Health Information Technologies --- Information Technologies, Health --- Information Technology, Health --- Medical Computer Sciences --- Medical Information Sciences --- Science, Medical Computer --- Technologies, Health Information --- Technology, Health Information --- Genetic Technic --- Genetic Technics --- Genetic Technique --- Technic, Genetic --- Technics, Genetic --- Technique, Genetic --- Techniques, Genetic --- Analysis, Sequence --- Determination, Sequence --- Determinations, Sequence --- Sequence Determinations --- Sequence Determination --- Analyses, Sequence --- Sequence Analyses --- Information Sciences --- Science, Information --- Sciences, Information --- Application, Medical Informatics --- Applications, Medical Informatics --- Informatics Applications, Medical --- Informatics Application, Medical --- Medical Informatics Application --- Investigative Technics --- Investigative Technic --- Investigative Technique --- Technic, Investigative --- Technics, Investigative --- Technique, Investigative --- Techniques, Investigative --- Typing, Molecular --- Analysis, DNA Sequence --- DNA Sequence Determination --- DNA Sequence Determinations --- DNA Sequencing --- Determination, DNA Sequence --- Determinations, DNA Sequence --- Sequence Determinations, DNA --- DNA Sequence Analysis --- Sequence Determination, DNA --- Analyses, DNA Sequence --- DNA Sequence Analyses --- Sequence Analyses, DNA --- Sequencing, DNA --- Data Files --- Data Linkage --- Data Retrieval --- Data Sources --- Data Storage --- Data Storage and Retrieval --- Information Extraction --- Information Storage --- Machine-Readable Data Files --- Information Retrieval --- Data File --- Data File, Machine-Readable --- Data Files, Machine-Readable --- Data Source --- Extraction, Information --- Files, Machine-Readable Data --- Information Extractions --- Machine Readable Data Files --- Machine-Readable Data File --- Retrieval, Data --- Storage, Data --- DNA bank databases --- DNA banking databases --- DNA databanks --- DNA databases --- Chromosome markers --- DNA markers --- Medicine. --- Human genetics. --- Plant genetics. --- Animal genetics. --- Biomedicine. --- Human Genetics. --- Animal Genetics and Genomics. --- Plant Genetics & Genomics. --- Plants --- Heredity, Human --- Human biology --- Physical anthropology --- Clinical sciences --- Medical profession --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Plant Genetics and Genomics.